薬理ゲノミクス・ゲノム創薬科学 - 京都大学大学院薬学研究科

Publications

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152 entries « ‹ 3 of 4 › »

2002

52.

Koshimizu, T. A.; Yamauchi, J.; Hirasawa, A.; Tanoue, A.; Tsujimoto, G.

Recent progress in alpha 1-adrenoceptor pharmacology Journal Article

In: Biol. Pharm. Bull., vol. 25, no. 4, pp. 401–408, 2002.

51.

Sugawara, T.; Hirasawa, A.; Hashimoto, K.; Tsujimoto, G.

Differences in the subcellular localization of alpha1-adrenoceptor subtypes can affect the subtype selectivity of drugs in a study with the fluorescent ligand BODIPY FL-prazosin Journal Article

In: Life Sci., vol. 70, no. 18, pp. 2113–2124, 2002.

50.

Yoshida, N.; Sugiyama, M.; Tanoue, A.; Hirasawa, A.; Saito, H.; Tsujimoto, G.

Determination of a novel haplotype of beta2-adrenergic receptor in the Japanese population by the combination of the electronic microchip assay using the NanoChip system with allele-specific PCR Journal Article

In: Drug Metab. Pharmacokinet., vol. 17, no. 6, pp. 532–539, 2002.

49.

Hashizume, K.; Ishiwata, H.; Kizaki, K.; Yamada, O.; Takahashi, T.; Imai, K.; Patel, O. V.; Akagi, S.; Shimizu, M.; Takahashi, S.; Katsuma, S.; Shiojima, S.; Hirasawa, A.; Tsujimoto, G.; Todoroki, J.; Izaike, Y.

Implantation and placental development in somatic cell clone recipient cows Journal Article

In: Cloning Stem Cells, vol. 4, no. 3, pp. 197–209, 2002.

48.

Yoshida, N.; Nishimaki, Y.; Sugiyama, M.; Abe, T.; Tatsumi, T.; Tanoue, A.; Hirasawa, A.; Tsujimoto, G.

SNP genotyping in the beta(2)-adrenergic receptor by electronic microchip assay, DHPLC, and direct sequencing Journal Article

In: J. Hum. Genet., vol. 47, no. 9, pp. 500–503, 2002.

47.

Katsuma, S.; Shiojima, S.; Hirasawa, A.; Suzuki, Y.; Ikawa, H.; Takagaki, K.; Kaminishi, Y.; Murai, M.; Ohgi, T.; Yano, J.; Tsujimoto, G.

Functional genomic search of G-protein-coupled receptors using microarrays with normalized cDNA library Journal Article

In: Meth. Enzymol., vol. 345, pp. 585–600, 2002.

2001

46.

Awaji, T.; Hirasawa, A.; Shirakawa, H.; Tsujimoto, G.; Miyazaki, S.

Novel green fluorescent protein-based ratiometric indicators for monitoring pH in defined intracellular microdomains Journal Article

In: Biochem. Biophys. Res. Commun., vol. 289, no. 2, pp. 457–462, 2001.

45.

Yamauchi, J.; Itoh, H.; Shinoura, H.; Miyamoto, Y.; Tsumaya, K.; Hirasawa, A.; Kaziro, Y.; Tsujimoto, G.

Galphaq-dependent activation of mitogen-activated protein kinase kinase 4/c-Jun N-terminal kinase cascade Journal Article

In: Biochem. Biophys. Res. Commun., vol. 288, no. 5, pp. 1087–1094, 2001.

44.

Katsuma, S.; Nishi, K.; Tanigawara, K.; Ikawa, H.; Shiojima, S.; Takagaki, K.; Kaminishi, Y.; Suzuki, Y.; Hirasawa, A.; Ohgi, T.; Yano, J.; Murakami, Y.; Tsujimoto, G.

Molecular monitoring of bleomycin-induced pulmonary fibrosis by cDNA microarray-based gene expression profiling Journal Article

In: Biochem. Biophys. Res. Commun., vol. 288, no. 4, pp. 747–751, 2001.

43.

Tsujimoto, G.; Katsuma, S.; Shiojima, S.; Hirasawa, A.; Tanoue, A.

Functional genomic research of alpha 1-adrenoceptors Journal Article

In: J. Cardiovasc. Pharmacol., vol. 38 Suppl 1, pp. 1–5, 2001.

42.

Takahara, A.; Hirasawa, A.; Dohmoto, H.; Shoji, M.; Yoshimoto, R.; Sugiyama, A.; Hashimoto, K.

In vivo antiarrhythmic profile of AP-792 assessed in different canine arrhythmia models Journal Article

In: Jpn. J. Pharmacol., vol. 87, no. 1, pp. 21–26, 2001.

41.

Yamauchi, J.; Hirasawa, A.; Miyamoto, Y.; Itoh, H.; Tsujimoto, G.

Beta2-adrenergic receptor/cyclic adenosine monophosphate (cAMP) leads to JNK activation through Rho family small GTPases Journal Article

In: Biochem. Biophys. Res. Commun., vol. 284, no. 5, pp. 1199–1203, 2001.

40.

Hirasawa, A.; Awaji, T.; Xu, Z.; Shinoura, H.; Tsujimoto, G.

Regulation of subcellular localization of alpha1-adrenoceptor subtypes Journal Article

In: Life Sci., vol. 68, no. 19-20, pp. 2259–2267, 2001.

39.

Yamauchi, J.; Itoh, H.; Shinoura, H.; Miyamoto, Y.; Hirasawa, A.; Kaziro, Y.; Tsujimoto, G.

Involvement of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase in alpha1B-adrenergic receptor/Galphaq-induced inhibition of cell proliferation Journal Article

In: Biochem. Biophys. Res. Commun., vol. 281, no. 4, pp. 1019–1023, 2001.

38.

Katsuma, S.; Shiojima, S.; Hirasawa, A.; Suzuki, Y.; Takagaki, K.; Murai, M.; Kaminishi, Y.; Hada, Y.; Koba, M.; Muso, E.; Miyawaki, S.; Ohgi, T.; Yano, J.; Tsujimoto, G.

Genomic analysis of a mouse model of immunoglobulin A nephropathy reveals an enhanced PDGF-EDG5 cascade Journal Article

In: Pharmacogenomics J., vol. 1, no. 3, pp. 211–217, 2001.

2000

37.

Homma, N.; Hirasawa, A.; Shibata, K.; Hashimito, K.; Tsujimoto, G.

Both alpha(1A)- and alpha(1B)-adrenergic receptor subtypes couple to the transient outward current (I(To)) in rat ventricular myocytes Journal Article

In: Br. J. Pharmacol., vol. 129, no. 6, pp. 1113–1120, 2000.

36.

Shinoura, H.; Take, H.; Itoh, S.; Hirasawa, A.; Inoue, K.; Ohno, Y.; Hashimoto, K.; Tsujimoto, G.

Key amino acids of vasopressin V1a receptor responsible for the species difference in the affinity of OPC-21268 Journal Article

In: FEBS Lett., vol. 466, no. 2-3, pp. 255–258, 2000.

1999

35.

Xu, Z.; Hirasawa, A.; Shinoura, H.; Tsujimoto, G.

Interaction of the alpha(1B)-adrenergic receptor with gC1q-R, a multifunctional protein Journal Article

In: J. Biol. Chem., vol. 274, no. 30, pp. 21149–21154, 1999.

1998

34.

Awaji, T.; Hirasawa, A.; Kataoka, M.; Shinoura, H.; Nakayama, Y.; Sugawara, T.; Izumi, S.; Tsujimoto, G.

Real-time optical monitoring of ligand-mediated internalization of alpha1b-adrenoceptor with green fluorescent protein Journal Article

In: Mol. Endocrinol., vol. 12, no. 8, pp. 1099–1111, 1998.

33.

Take, H.; Shibata, K.; Awaji, T.; Hirasawa, A.; Ikegaki, I.; Asano, T.; Takada, T.; Tsujimoto, G.

Vascular alpha1-adrenoceptor subtype selectivity and alpha1-blocker-induced orthostatic hypotension Journal Article

In: Jpn. J. Pharmacol., vol. 77, no. 1, pp. 61–70, 1998.

32.

Hirasawa, A.; Awaji, T.; Sugawara, T.; Tsujimoto, A.; Tsujimoto, G.

Differential mechanism for the cell surface sorting and agonist-promoted internalization of the alpha1B-adrenoceptor Journal Article

In: Br. J. Pharmacol., vol. 124, no. 1, pp. 55–62, 1998.

31.

Shibata, K.; Hirasawa, A.; Foglar, R.; Ogawa, S.; Tsujimoto, G.

Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors Journal Article

In: Circulation, vol. 97, no. 13, pp. 1227–1230, 1998.

30.

Tsujimoto, G.; Hirasawa, A.; Sugawara, T.; Awaji, T.

Subtype-specific differences in subcellular localization and chlorethylclonidine inactivation of alpha1-adrenoceptors Journal Article

In: Life Sci., vol. 62, no. 17-18, pp. 1567–1571, 1998.

1997

29.

Hirasawa, A.; Sugawara, T.; Awaji, T.; Tsumaya, K.; Ito, H.; Tsujimoto, G.

Subtype-specific differences in subcellular localization of alpha1-adrenoceptors: chlorethylclonidine preferentially alkylates the accessible cell surface alpha1-adrenoceptors irrespective of the subtype Journal Article

In: Mol. Pharmacol., vol. 52, no. 5, pp. 764–770, 1997.

1996

28.

Hirasawa, A.; Athauda, S. B.; Takahashi, K.

Purification and characterization of turtle pepsinogen and pepsin Journal Article

In: J. Biochem., vol. 120, no. 2, pp. 407–414, 1996.

27.

Awaji, T.; Izumi, S.; Horie, K.; Hirasawa, A.; Tsujimoto, G.

Alpha 1b-adrenoceptor-mediated calcium oscillation is specific for the S phase in cell cycle and dependent on the extracellular calcium Journal Article

In: Biochem. Biophys. Res. Commun., vol. 224, no. 1, pp. 80–86, 1996.

26.

Shibata, K.; Hirasawa, A.; Moriyama, N.; Kawabe, K.; Ogawa, S.; Tsujimoto, G.

Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy Journal Article

In: Br. J. Pharmacol., vol. 118, no. 6, pp. 1403–1408, 1996.

25.

Hirasawa, A.; Tsumaya, K.; Awaji, T.; Shibata, K.; Homma, N.; Shinomiya, T.; Tsujimoto, G.

Flow cytometry analysis of alpha1-adrenoceptor subtypes Journal Article

In: FEBS Lett., vol. 386, no. 2-3, pp. 141–148, 1996.

24.

Yazawa, H.; Hirasawa, A.; Horie, K.; Saita, Y.; Iida, E.; Honda, K.; Tsujimoto, G.

Oxytocin receptors expressed and coupled to Ca2+ signalling in a human vascular smooth muscle cell line Journal Article

In: Br. J. Pharmacol., vol. 117, no. 5, pp. 799–804, 1996.

1995

23.

Hirasawa, A.; Awaji, T.; Tsujimoto, G.

[Flow cytometry and laser scanning confocal microscopy analysis of the receptor distribution] Journal Article

In: Nippon Yakurigaku Zasshi, vol. 106, no. 4, pp. 255–261, 1995.

22.

Kato, Y.; Igarashi, N.; Hirasawa, A.; Tsujimoto, G.; Kobayashi, M.

Distribution and developmental changes in vasopressin V2 receptor mRNA in rat brain Journal Article

In: Differentiation, vol. 59, no. 3, pp. 163–169, 1995.

21.

Esbenshade, T. A.; Hirasawa, A.; Tsujimoto, G.; Tanaka, T.; Yano, J.; Minneman, K. P.; Murphy, T. J.

Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells Journal Article

In: Mol. Pharmacol., vol. 47, no. 5, pp. 977–985, 1995.

20.

Hashimoto, K.; Haruno, A.; Hirasawa, A.; Awaji, T.; Xue, Y.; Wu, Z.

Effects of the new class III antiarrhythmic drug MS-551 and d-sotalol on canine coronary ligation-reperfusion ventricular arrhythmias Journal Article

In: Jpn. J. Pharmacol., vol. 68, no. 1, pp. 1–9, 1995.

19.

Hirasawa, A.; Shibata, K.; Horie, K.; Takei, Y.; Obika, K.; Tanaka, T.; Muramoto, N.; Takagaki, K.; Yano, J.; Tsujimoto, G.

Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants Journal Article

In: FEBS Lett., vol. 363, no. 3, pp. 256–260, 1995.

18.

Hirasawa, A.; Tsujimoto, G.; Okuyama, S.; Li, X. K.; Iwaya, M.; Masaki, Y.; Yokoi, Y.; Nakamura, S.; Baba, S.; Miyamoto, M.

Polymerase chain reaction of the rat sex-determining region of the Y-chromosome and its application to estimating a state of sensitization to minor histocompatibility antigen H-Y Journal Article

In: Transplant. Proc., vol. 27, no. 2, pp. 1598–1600, 1995.

17.

Hara, M.; Shibata, K.; Hirasawa, A.; Iwaya, M.; Okuyama, S.; Tsujimoto, G.; Kimura, H.; Koga, Y.

Microchimerism and lung allograft acceptance Journal Article

In: Transplant. Proc., vol. 27, no. 2, pp. 1580–1582, 1995.

16.

Kaneko, H.; Iizuka, K.; Kokai, Y.; Fujimoto, J. I.; Hirasawa, A.; Tsujimoto, G.; Koike, H.; Torres-Nagel, N.; Hunig, T.; Kimura, H.

Vaccination with a synthetic T-cell receptor V-region peptide: immunomodulation or vaccination Journal Article

In: Transplant. Proc., vol. 27, no. 2, pp. 1539–1542, 1995.

15.

Masaki, Y.; Hirasawa, A.; Okuyama, S.; Tsujimoto, G.; Iwaya, M.; Li, X. K.; Yokoi, Y.; Nakamura, S.; Baba, S.; Miyamoto, M.

Microchimerism and heart allograft acceptance Journal Article

In: Transplant. Proc., vol. 27, no. 1, pp. 148–150, 1995.

14.

Suzuki, H.; Shibata, H.; Murakami, M.; Sato, A.; Naito, M.; Ichihara, A.; Matsumoto, A.; Tsujimoto, G.; Hirasawa, A.; Horie, K.

Modulation of angiotensin II type 1 receptor mRNA expression in human blood cells: comparison of platelets and mononuclear leucocytes Journal Article

In: Endocr. J., vol. 42, no. 1, pp. 15–22, 1995.

13.

Foglar, R.; Shibata, K.; Horie, K.; Hirasawa, A.; Tsujimoto, G.

Use of recombinant alpha 1-adrenoceptors to characterize subtype selectivity of drugs for the treatment of prostatic hypertrophy Journal Article

In: Eur. J. Pharmacol., vol. 288, no. 2, pp. 201–207, 1995.

12.

Takahashi, K.; Tanji, M.; Yakabe, E.; Hirasawa, A.; Athauda, S. B.; Kageyama, T.

Non-mammalian vertebrate pepsinogens and pepsins: isolation and characterization Journal Article

In: Adv. Exp. Med. Biol., vol. 362, pp. 53–65, 1995.

1994

11.

Hirasawa, A.; Nakayama, Y.; Ishiharada, N.; Honda, K.; Saito, R.; Tsujimoto, G.; Takano, Y.; Kamiya, H.

Evidence for the existence of vasopressin V2 receptor mRNA in rat hippocampus Journal Article

In: Biochem. Biophys. Res. Commun., vol. 205, no. 3, pp. 1702–1706, 1994.

10.

Hirasawa, A.; Shibata, K.; Kotosai, K.; Tsujimoto, G.

Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor Journal Article

In: Biochem. Biophys. Res. Commun., vol. 203, no. 1, pp. 72–79, 1994.

Horie, K.; Hirasawa, A.; Tsujimoto, G.

The pharmacological profile of cloned and stably expressed alpha 1b-adrenoceptor in CHO cells Journal Article

In: Eur. J. Pharmacol., vol. 268, no. 3, pp. 399–407, 1994.

Hirasawa, A.; Hashimoto, K.; Tsujimoto, G.

Distribution and developmental change of vasopressin V1A and V2 receptor mRNA in rats Journal Article

In: Eur. J. Pharmacol., vol. 267, no. 1, pp. 71–75, 1994.

1993

Hirasawa, A.; Awaji, T.; Hosono, M.; Haruno, A.; Hashimoto, K.

Effects of a new forskolin derivative, NKH477, on canine ventricular arrhythmia models Journal Article

In: J. Cardiovasc. Pharmacol., vol. 22, no. 6, pp. 847–851, 1993.

Hirasawa, A.; Horie, K.; Tanaka, T.; Takagaki, K.; Murai, M.; Yano, J.; Tsujimoto, G.

Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor Journal Article

In: Biochem. Biophys. Res. Commun., vol. 195, no. 2, pp. 902–909, 1993.

Horie, K.; Hirasawa, A.; Masuda, K.; Tsujimoto, G.

Identification of alpha 1C-adrenergic receptor mRNA in bovine retinal pigment epithelium Journal Article

In: Invest. Ophthalmol. Vis. Sci., vol. 34, no. 9, pp. 2769–2775, 1993.

Zhenjiu, W.; Awaji, T.; Hirasawa, A.; Motomura, S.; Hashimoto, K.

Effects of a new class I antiarrhythmic drug bidisomide on canine ventricular arrhythmia models Journal Article

In: Mol. Cell. Biochem., vol. 119, no. 1-2, pp. 159–169, 1993.

1992

Hirasawa, A.; Haruno, A.; Matsuzaki, T.; Hashimoto, K.

Effects of a new antiarrhythmic drug, SD-3212, on canine ventricular arrhythmia models Journal Article

In: Jpn Heart J, vol. 33, no. 6, pp. 851–861, 1992.

152 entries « ‹ 3 of 4 › »