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152 entries « 1 of 4 »

2024

152.

Goto, Ai; Kambayashi, Ryuichi; Chiba, Koki; Shinozaki, Makoto; Moritani, Kiryu; Izumi-Nakaseko, Hiroko; Takei, Yoshinori; Hirasawa, Akira; Sugiyama, Atsushi

Analyses of the onset mechanisms of cardio-stimulatory action by aciclovir Journal Article

In: Journal of Pharmacological Sciences, vol. 154, no. 4, pp. 294-300, 2024, ISSN: 1347-8613.

Abstract | Links

2023

151.

Higuchi, Sayaka; Suehiro, Yuji; Izuhara, Luna; Yoshina, Sawako; Hirasawa, Akira; Mitani, Shohei

BCL7B, a SWI/SNF complex subunit, orchestrates cancer immunity and stemness Journal Article

In: BMC Cancer, vol. 23, no. 1, pp. 811, 2023, ISSN: 1471-2407.

Abstract | Links

150.

Yasuda, Takuma; Harada, Norio; Hatoko, Tomonobu; Ichimura, Atsuhiko; Ikeguchi-Ogura, Eri; Murata, Yuki; Wada, Naoki; Kiyobayashi, Sakura; Yamane, Shunsuke; Hirasawa, Akira; Inagaki, Nobuya

Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding Journal Article

In: Am J Physiol Endocrinol Metab, vol. 324, no. 5, pp. E449–E460, 2023, ISSN: 1522-1555.

Abstract | Links

2022

149.

Takei, Yoshinori; Amagase, Yoko; Iida, Keiko; Sagawa, Tomohiro; Goto, Ai; Kambayashi, Ryuichi; Izumi-Nakaseko, Hiroko; Matsumoto, Akio; Kawai, Shinichi; Sugiyama, Atsushi; Takada, Tatsuyuki; Hirasawa, Akira

Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory. Journal Article

In: GeroScience, 2022.

Links

2021

148.

Iwasa, Kensuke; Yamamoto, Shinji; Yamashina, Kota; Yagishita-Kyo, Nan; Maruyama, Kei; Awaji, Takeo; Takei, Yoshinori; Hirasawa, Akira; Yoshikawa, Keisuke

A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus. Journal Article

In: Journal of neuroinflammation, vol. 18, no. 1, pp. 304–304, 2021.

Links

147.

Murata, Yuki; Harada, Norio; Kishino, Shigenobu; Iwasaki, Kanako; Ikeguchi-Ogura, Eri; Yamane, Shunsuke; Kato, Tomoko; Kanemaru, Yoshinori; Sankoda, Akiko; Hatoko, Tomonobu; Kiyobayashi, Sakura; Ogawa, Jun; Hirasawa, Akira; Inagaki, Nobuya

Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK Journal Article

In: iScience, vol. 24, no. 9, pp. 102963–102963, 2021.

Links

146.

Sotome, Rina; Hirasawa, Akira; Kikusato, Motoi; Amo, Taku; Furukawa, Kyohei; Kuriyagawa, Anna; Watanabe, Kouichi; Collin, Anne; Shirakawa, Hitoshi; Hirakawa, Ryota; Tanitaka, Yuta; Takahashi, Hideki; Wu, Guoyao; Nochi, Tomonori; Shimmura, Tsuyoshi; Warden, Craig H.; Toyomizu, Masaaki

In vivo emergence of beige-like fat in chickens as physiological adaptation to cold environments Journal Article

In: Amino Acids, vol. 53, no. 3, pp. 381–393, 2021.

Links

145.

Sadamura, Yuko; Thapa, Shanta; Mizunuma, Ryota; Kambe, Yuki; Hirasawa, Akira; Nakamoto, Kazuo; Tokuyama, Shogo; Yoshimoto, Koji; Arita, Kazunori; Miyata, Atsuro; Oyoshi, Tatsuki; Kurihara, Takashi

FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice. Journal Article

In: Frontiers in pharmacology, vol. 12, pp. 699026–699026, 2021.

Links

2020

144.

Takada, Eri; Okubo, Kaori; Yano, Yoshiaki; Iida, Keiko; Someda, Masataka; Hirasawa, Akira; Yonehara, Shin; Matsuzaki, Katsumi

Molecular Mechanism of Apoptosis by Amyloid β-Protein Fibrils Formed on Neuronal Cells Journal Article

In: ACS Chemical Neuroscience, vol. 11, no. 5, pp. 796–805, 2020.

Links

143.

Wang, Tianyu; Nakagawa, Shumpei; Miyake, Takahito; Setsu, Genzui; Kunisue, Sumihiro; Goto, Kaoru; Hirasawa, Akira; Okamura, Hitoshi; Yamaguchi, Yoshiaki; Doi, Masao

Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176 Journal Article

In: Scientific Reports, vol. 10, pp. 4429–, 2020.

142.

Tsuyuguchi, Masato; Nakaniwa, Tetsuko; Hirasawa, Akira; Nakanishi, Isao; Kinoshita, Takayoshi

Structural insights for producing CK2α1-specific inhibitors. Journal Article

In: Bioorganic & medicinal chemistry letters, vol. 30, no. 2, pp. 126837–126837, 2020.

Links

2019

141.

Nishino, Katsutoshi; Uesugi, Haruka; Hirasawa, Akira; Ohtera, Anna; Miyamae, Yusaku; Neffati, Mohamed; Isoda, Hiroko; Kambe, Taiho; Masuda, Seiji; Irie, Kazuhiro; Nagao, Masaya

Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1 Journal Article

In: Biochemical and biophysical research communications, vol. 522, no. 1, pp. 68–73, 2019.

Links

140.

Sankoda, Akiko; Harada, Norio; Kato, Tomoko; Ikeguchi, Eri; Iwasaki, Kanako; Yamane, Shunsuke; Murata, Yuki; Hirasawa, Akira; Inagaki, Nobuya

Free fatty acid receptors, G protein-coupled receptor 120 and G protein-coupled receptor 40, are essential for oil-induced gastric inhibitory polypeptide secretion. Journal Article

In: Journal of diabetes investigation, vol. 10, no. 6, pp. 1430–1437, 2019.

Links

139.

Tanaka, Tomoaki; Ono, Yuriko; Hikihara, Naoki; Yoshida, Ayana; Yamada, Hasumi; Higaki, Shogo; Nishie, Tomomi; Tooyama, Ikuo; Iida, Keiko; Hirasawa, Akira; Takada, Tatsuyuki

Transcriptome analysis revealed bisphenol A and nonylphenol affect reproduction. Journal Article

In: Reproductive toxicology (Elmsford, N.Y.), vol. 88, pp. 39–47, 2019.

Links

138.

Free fatty acid receptor GPR120 and GPR40 are essential for oil-induced GIP secretion. Journal Article

In: J Diabetes Investig., 2019.

2018

137.

TA, Koshimizu; K, Honda; S, Nagaoka-Uozumi; A, Ichimura; I, Kimura; M, Nakaya; N, Sakai; K, Shibata; K, Ushijima; A, Fujimura; A, Hirasawa; H, Kurose; G, Tsujimoto; A, Tanoue; Y, Takano

Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance. Journal Article

In: Nature neuroscience, vol. 21, no. 6, pp. 820–833, 2018.

Links

136.

Nakamoto, Kazuo; Shimada, Koki; Harada, Shinichi; Morimoto, Yasuko; Hirasawa, Akira; Tokuyama, Shogo

DHA supplementation prevent the progression of NASH via GPR120 signaling Journal Article

In: European Journal of Pharmacology, vol. 820, pp. 31–38, 2018.

Links

2017

135.

Aizawa, Fuka; Ogaki, Yoshihiro; Kyoya, Natsuki; Nishinaka, Takashi; Nakamoto, Kazuo; Kurihara, Takashi; Hirasawa, Akira; Miyata, Atsuro; Tokuyama, Shogo

The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice Journal Article

In: BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 40, no. 8, pp. 1255–1259, 2017.

Links

134.

Nakamoto, Kazuo; Aizawa, Fuka; Miyagi, Kei; Yamashita, Takuya; Mankura, Mitsumasa; Koyama, Yutaka; Kasuya, Fumiyo; Hirasawa, Akira; Kurihara, Takashi; Miyata, Atsuro; Tokuyama, Shogo

Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice Journal Article

In: PLOS ONE, vol. 12, no. 7, pp. e0180610–, 2017.

Links

133.

Yagishita, Sosuke; Hirasawa, Akira

Intermittent hypoxia produces Alzheimer disease? Journal Article

In: ONCOTARGET, vol. 8, no. 26, pp. 41786–41787, 2017.

Links

132.

Houthuijzen, Julia M.; Oosterom, Ilse; Hudson, Brian D.; Hirasawa, Akira; Daenen, Laura G. M.; McLean, Chelsea M.; Hansen, Steffen V. F.; Jaarsveld, Marijn T. M.; Peeper, Daniel S.; Sadatmand, Sahar Jafari; Roodhart, Jeanine M. L.; Lest, Chris H. A.; Ulven, Trond; Ishihara, Kenji; Milligan, Graeme; Voest, Emile E.

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance Journal Article

In: FASEB JOURNAL, vol. 31, no. 5, pp. 2195–2209, 2017.

Links

131.

Sankoda, Akiko; Harada, Norio; Iwasaki, Kanako; Yamane, Shunsuke; Murata, Yuki; Shibue, Kimitaka; Thewjitcharoen, Yotsapon; Suzuki, Kazuyo; Harada, Takanari; Kanemaru, Yoshinori; Shimazu-Kuwahara, Satoko; Hirasawa, Akira; Inagaki, Nobuya

Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice Journal Article

In: ENDOCRINOLOGY, vol. 158, no. 5, pp. 1172–1180, 2017.

Links

130.

Villegas-Comonfort, S.; Takei, Y.; Tsujimoto, G.; Hirasawa, A.; Garcia-Sainz, J. A.

Effects of arachidonic acid on FFA4 receptor: Signaling, phosphorylation and internalization Journal Article

In: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol. 117, pp. 1–10, 2017.

Links

129.

Yagishita, Sosuke; Suzuki, Seiya; Yoshikawa, Keisuke; Iida, Keiko; Hirata, Ayako; Suzuki, Masahiko; Takashima, Akihiko; Maruyama, Kei; Hirasawa, Akira; Awaji, Takeo

Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging Journal Article

In: MOLECULAR BRAIN, vol. 10, no. 1, pp. 2–, 2017.

Links

2016

128.

Aizawa, Fuka; Nishinaka, Takashi; Yamashita, Takuya; Nakamoto, Kazuo; Kurihara, Takashi; Hirasawa, Akira; Kasuya, Fumiyo; Miyata, Atsuro; Tokuyama, Shogo

GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior Journal Article

In: JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 132, no. 4, pp. 249–254, 2016.

Links

2015

127.

Ancel, D.; Bernard, A.; Subramaniam, S.; Hirasawa, A.; Tsujimoto, G.; Hashimoto, T.; Passilly-Degrace, P.; Khan, N. A.; Besnard, P.

The oral lipid sensor GPR120 is not indispensable for the orosensory detection of dietary lipids in mice Journal Article

In: J. Lipid Res., vol. 56, no. 2, pp. 369–378, 2015.

Links

126.

Sosa-Alvarado, Carla; Hernandez-Mendez, Aurelio; Romero-Avila, M. Teresa; Sanchez-Reyes, Omar B.; Takei, Yoshinori; Tsujimoto, Gozoh; Hirasawa, Akira; Garcia-Sainz, J. Adolfo

Agonists and protein kinase C-activation induce phosphorylation and internalization of FFA1 receptors Journal Article

In: EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 768, pp. 108–115, 2015.

Links

125.

Shi, Junfeng; Liu, Ning; Xiao, Ying; Takei, Yoshinori; Yasue, Misato; Suzuki, Yamato; Hou, Zengye; Ohno, Hiroaki; Yamada, Masateru; Fuchi, Nobuhiro; Oshida, Keiyu; Miyamoto, Yohei; Tsujimoto, Gozoh; Hirasawa, Akira

The Effects of a Selective CK2 Inhibitor on Anti-glomerular Basement Membrane Glomerulonephritis in Rats Journal Article

In: BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 38, no. 9, pp. 1345–1351, 2015.

Links

124.

Liu, Ning; Shi, Junfeng; Xiao, Ying; Yasue, Misato; Takei, Yoshinori; Sanefuji, Hayato; Tsujimoto, Gozoh; Hirasawa, Akira

Effects of a Tricaprylin Emulsion on Anti-glomerular Basement Membrane Glomerulonephritis in Rats: In Vivo and in Silico Studies Journal Article

In: BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 38, no. 8, pp. 1175–1184, 2015.

Links

123.

Nakanishi, Isao; Murata, Katsumi; Nagata, Naoya; Kurono, Masakuni; Kinoshita, Takayoshi; Yasue, Misato; Miyazaki, Takako; Takei, Yoshinori; Nakamura, Shinya; Sakurai, Atsushi; Iwamoto, Nobuko; Nishiwaki, Keiji; Nakaniwa, Tetsuko; Sekiguchi, Yusuke; Hirasawa, Akira; Tsujimoto, Gozoh; Kitaura, Kazuo

Identification of protein kinase CK2 inhibitors using solvent dipole ordering virtual screening Journal Article

In: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 96, pp. 396–404, 2015.

Links

122.

Ancel, Deborah; Bernard, Arnaud; Subramaniam, Selvakumar; Hirasawa, Akira; Tsujimoto, Gozoh; Hashimoto, Toshihiro; Passilly-Degrace, Patricia; Khan, Naim-Akhtar; Besnard, Philippe

The oral lipid sensor GPR120 is not indispensable for the orosensory detection of dietary lipids in mice Journal Article

In: JOURNAL OF LIPID RESEARCH, vol. 56, no. 2, pp. 369–378, 2015.

Links

121.

Hirasawa, Akira; Takeuchi, Masato; Hara, Takafumi; Hirata, Ayako; Tanabe, Soshi; Umeda, Naoya

Fatty acids receptors Journal Article

In: Bioactive Lipid Mediators: Current Reviews and Protocols, pp. 139–154, 2015.

Links

120.

K, Iwasaki; N, Harada; K, Sasaki; S, Yamane; K, Iida; K, Suzuki; A, Hamasaki; D, Nasteska; K, Shibue; E, Joo; T, Harada; T, Hashimoto; Y, Asakawa; A, Hirasawa; N, Inagaki

Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion. Journal Article

In: Endocrinology., vol. 156, no. 3, pp. 837–846, 2015.

Links

119.

Furutani, Akiko; Ikeda, Yuko; Itokawa, Misa; Nagahama, Hiroki; Ohtsu, Teiji; Furutani, Naoki; Kamagata, Mayo; Yang, Zhi-Hong; Hirasawa, Akira; Tahara, Yu; Shibata, Shigenobu

Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120. Journal Article

In: PloS one, vol. 10, no. 7, pp. e0132472–, 2015.

Links

2014

118.

Iwasaki, K.; Harada, N.; Sasaki, K.; Yamane, S.; Iida, K.; Suzuki, K.; Hamasaki, A.; Nasteska, D.; Shibue, K.; Joo, E.; Harada, T.; Hashimoto, T.; Asakawa, Y.; Hirasawa, A.; Inagaki, N.

Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K-cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion Journal Article

In: Endocrinology, pp. en20141653, 2014.

Links

117.

Hara, T.; Kashihara, D.; Ichimura, A.; Kimura, I.; Tsujimoto, G.; Hirasawa, A.

Role of free fatty acid receptors in the regulation of energy metabolism Journal Article

In: Biochim. Biophys. Acta, vol. 1841, no. 9, pp. 1292–1300, 2014.

Links

116.

Kaneda, M.; Misu, R.; Ohno, H.; Hirasawa, A.; Ieda, N.; Uenoyama, Y.; Tsukamura, H.; Maeda, K.; Oishi, S.; Fujii, N.

Design and synthesis of fluorescent probes for GPR54 Journal Article

In: Bioorg. Med. Chem., vol. 22, no. 13, pp. 3325–3330, 2014.

Links

115.

Ichimura, A.; Hara, T.; Hirasawa, A.

Regulation of Energy Homeostasis via GPR120 Journal Article

In: Front Endocrinol (Lausanne), vol. 5, pp. 111, 2014.

Links

114.

Hara, T.; Ichimura, A.; Hirasawa, A.

Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors Journal Article

In: Front Endocrinol (Lausanne), vol. 5, pp. 83, 2014.

Links

113.

Sanchez-Reyes, O. B.; Romero-Avila, M. T.; Castillo-Badillo, J. A.; Takei, Y.; Hirasawa, A.; Tsujimoto, G.; Villalobos-Molina, R.; Garcia-Sainz, J. A.

Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation Journal Article

In: Eur. J. Pharmacol., vol. 723, pp. 368–374, 2014.

Links

2013

112.

Hou, Z.; Oishi, S.; Suzuki, Y.; Kure, T.; Nakanishi, I.; Hirasawa, A.; Tsujimoto, G.; Ohno, H.; Fujii, N.

Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors Journal Article

In: Org. Biomol. Chem., vol. 11, no. 20, pp. 3288–3296, 2013.

Links

111.

Takeuchi, M.; Hirasawa, A.; Hara, T.; Kimura, I.; Hirano, T.; Suzuki, T.; Miyata, N.; Awaji, T.; Ishiguro, M.; Tsujimoto, G.

FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models Journal Article

In: Br. J. Pharmacol., vol. 168, no. 7, pp. 1570–1583, 2013.

Links

2012

110.

Hara, T.; Hirasawa, A.; Ichimura, A.; Kimura, I.; Tsujimoto, G.

Physiological functions of fatty acid receptors and their therapeutic potential Journal Article

In: Nippon Yakurigaku Zasshi, vol. 140, no. 6, pp. 275–279, 2012.

Links

109.

Suzuki, Y.; Oishi, S.; Takei, Y.; Yasue, M.; Misu, R.; Naoe, S.; Hou, Z.; Kure, T.; Nakanishi, I.; Ohno, H.; Hirasawa, A.; Tsujimoto, G.; Fujii, N.

Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles Journal Article

In: Org. Biomol. Chem., vol. 10, no. 25, pp. 4907–4915, 2012.

Links

108.

Masuda, R.; Oishi, S.; Tanahara, N.; Ohno, H.; Hirasawa, A.; Tsujimoto, G.; Yano, Y.; Matsuzaki, K.; Navenot, J. M.; Peiper, S. C.; Fujii, N.

Paradoxical Downregulation of CXC Chemokine Receptor 4 Induced by Polyphemusin II-Derived Antagonists Journal Article

In: Bioconjug. Chem., vol. 23, no. 6, pp. 1259–1265, 2012.

Links

107.

Masuda, R.; Oishi, S.; Tanahara, N.; Ohno, H.; Hirasawa, A.; Tsujimoto, G.; Kodama, E.; Matsuoka, M.; Fujii, N.

Development and application of fluorescent SDF-1 derivatives Journal Article

In: Future Med Chem, vol. 4, no. 7, pp. 837–844, 2012.

Links

106.

Inoue, D.; Kimura, I.; Wakabayashi, M.; Tsumoto, H.; Ozawa, K.; Hara, T.; Takei, Y.; Hirasawa, A.; Ishihama, Y.; Tsujimoto, G.

Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation Journal Article

In: FEBS Lett., vol. 586, no. 10, pp. 1547–1554, 2012.

Links

105.

Hou, Z.; Nakanishi, I.; Kinoshita, T.; Takei, Y.; Yasue, M.; Misu, R.; Suzuki, Y.; Nakamura, S.; Kure, T.; Ohno, H.; Murata, K.; Kitaura, K.; Hirasawa, A.; Tsujimoto, G.; Oishi, S.; Fujii, N.

Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds Journal Article

In: J. Med. Chem., vol. 55, no. 6, pp. 2899–2903, 2012.

Links

104.

Ichimura, A.; Hirasawa, A.; Poulain-Godefroy, O.; Bonnefond, A.; Hara, T.; Yengo, L.; Kimura, I.; Leloire, A.; Liu, N.; Iida, K.; Choquet, H.; Besnard, P.; Lecoeur, C.; Vivequin, S.; Ayukawa, K.; Takeuchi, M.; Ozawa, K.; Tauber, M.; Maffeis, C.; Morandi, A.; Buzzetti, R.; Elliott, P.; Pouta, A.; Jarvelin, M. R.; Korner, A.; Kiess, W.; Pigeyre, M.; Caiazzo, R.; Hul, W. Van; Gaal, L. Van; Horber, F.; Balkau, B.; Levy-Marchal, C.; Rouskas, K.; Kouvatsi, A.; Hebebrand, J.; Hinney, A.; Scherag, A.; Pattou, F.; Meyre, D.; Koshimizu, T. A.; Wolowczuk, I.; Tsujimoto, G.; Froguel, P.

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human Journal Article

In: Nature, vol. 483, no. 7389, pp. 350–354, 2012.

Links

2011

103.

Kinoshita, T.; Sekiguchi, Y.; Fukada, H.; Nakaniwa, T.; Tada, T.; Nakamura, S.; Kitaura, K.; Ohno, H.; Suzuki, Y.; Hirasawa, A.; Nakanishi, I.; Tsujimoto, G.

A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase Journal Article

In: Mol. Cell. Biochem., vol. 356, no. 1-2, pp. 97–105, 2011.

Links

152 entries « 1 of 4 »