Publications

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152 entries « ‹ 2 of 4 › »

2011

102.

Hara, T.; Hirasawa, A.; Ichimura, A.; Kimura, I.; Tsujimoto, G.

Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders Journal Article

In: J Pharm Sci, vol. 100, no. 9, pp. 3594–3601, 2011.

Links

101.

Kimura, I.; Inoue, D.; Maeda, T.; Hara, T.; Ichimura, A.; Miyauchi, S.; Kobayashi, M.; Hirasawa, A.; Tsujimoto, G.

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41) Journal Article

In: Proc. Natl. Acad. Sci. U.S.A., vol. 108, no. 19, pp. 8030–8035, 2011.

Links

2010

100.

Sun, Q.; Hirasawa, A.; Hara, T.; Kimura, I.; Adachi, T.; Awaji, T.; Ishiguro, M.; Suzuki, T.; Miyata, N.; Tsujimoto, G.

Structure-activity relationships of GPR120 agonists based on a docking simulation Journal Article

In: Mol. Pharmacol., vol. 78, no. 5, pp. 804–810, 2010.

Links

99.

Kimura, I.; Nakayama, Y.; Konishi, M.; Kobayashi, T.; Mori, M.; Ito, M.; Hirasawa, A.; Tsujimoto, G.; Ohta, M.; Itoh, N.; Fujimoto, M.

Neuferricin, a novel extracellular heme-binding protein, promotes neurogenesis Journal Article

In: J. Neurochem., vol. 112, no. 5, pp. 1156–1167, 2010.

Links

98.

Koshimizu, T. A.; Tsuchiya, H.; Tsuda, H.; Fujiwara, Y.; Shibata, K.; Hirasawa, A.; Tsujimoto, G.; Fujimura, A.

Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment Journal Article

In: Biochem. Biophys. Res. Commun., vol. 392, no. 4, pp. 603–607, 2010.

Links

97.

Miyauchi, S.; Hirasawa, A.; Ichimura, A.; Hara, T.; Tsujimoto, G.

New frontiers in gut nutrient sensor research: free fatty acid sensing in the gastrointestinal tract Journal Article

In: J. Pharmacol. Sci., vol. 112, no. 1, pp. 19–24, 2010.

Links

2009

96.

Ichimura, A.; Hirasawa, A.; Hara, T.; Tsujimoto, G.

Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis Journal Article

In: Prostaglandins Other Lipid Mediat., vol. 89, no. 3-4, pp. 82–88, 2009.

Links

95.

Hara, T.; Hirasawa, A.; Sun, Q.; Sadakane, K.; Itsubo, C.; Iga, T.; Adachi, T.; Koshimizu, T. A.; Hashimoto, T.; Asakawa, Y.; Tsujimoto, G.

Novel selective ligands for free fatty acid receptors GPR120 and GPR40 Journal Article

In: Naunyn Schmiedebergs Arch. Pharmacol., vol. 380, no. 3, pp. 247–255, 2009.

Links

94.

Sekiguchi, Y.; Nakaniwa, T.; Kinoshita, T.; Nakanishi, I.; Kitaura, K.; Hirasawa, A.; Tsujimoto, G.; Tada, T.

Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid Journal Article

In: Bioorg. Med. Chem. Lett., vol. 19, no. 11, pp. 2920–2923, 2009.

Links

93.

Miyauchi, S.; Hirasawa, A.; Iga, T.; Liu, N.; Itsubo, C.; Sadakane, K.; Hara, T.; Tsujimoto, G.

Distribution and regulation of protein expression of the free fatty acid receptor GPR120 Journal Article

In: Naunyn Schmiedebergs Arch. Pharmacol., vol. 379, no. 4, pp. 427–434, 2009.

Links

92.

Kimura, I.; Konishi, M.; Asaki, T.; Furukawa, N.; Ukai, K.; Mori, M.; Hirasawa, A.; Tsujimoto, G.; Ohta, M.; Itoh, N.; Fujimoto, M.

Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade Journal Article

In: Biochem. Biophys. Res. Commun., vol. 381, no. 1, pp. 75–80, 2009.

Links

91.

Nakaniwa, T.; Kinoshita, T.; Sekiguchi, Y.; Tada, T.; Nakanishi, I.; Kitaura, K.; Suzuki, Y.; Ohno, H.; Hirasawa, A.; Tsujimoto, G.

Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor Journal Article

In: Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., vol. 65, no. Pt 2, pp. 75–79, 2009.

90.

Hara, T.; Hirasawa, A.; Sun, Q.; Koshimizu, T. A.; Itsubo, C.; Sadakane, K.; Awaji, T.; Tsujimoto, G.

Flow cytometry-based binding assay for GPR40 (FFAR1; free fatty acid receptor 1) Journal Article

In: Mol. Pharmacol., vol. 75, no. 1, pp. 85–91, 2009.

2008

89.

Suzuki, T.; Igari, S.; Hirasawa, A.; Hata, M.; Ishiguro, M.; Fujieda, H.; Itoh, Y.; Hirano, T.; Nakagawa, H.; Ogura, M.; Makishima, M.; Tsujimoto, G.; Miyata, N.

Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists Journal Article

In: J. Med. Chem., vol. 51, no. 23, pp. 7640–7644, 2008.

88.

Hirasawa, A.; Hara, T.; Katsuma, S.; Adachi, T.; Tsujimoto, G.

Free fatty acid receptors and drug discovery Journal Article

In: Biol. Pharm. Bull., vol. 31, no. 10, pp. 1847–1851, 2008.

87.

Suzuki, Y.; Cluzeau, J.; Hara, T.; Hirasawa, A.; Tsujimoto, G.; Oishi, S.; Ohno, H.; Fujii, N.

Structure-activity relationships of pyrazine-based CK2 inhibitors: synthesis and evaluation of 2,6-disubstituted pyrazines and 4,6-disubstituted pyrimidines Journal Article

In: Arch. Pharm. (Weinheim), vol. 341, no. 9, pp. 554–561, 2008.

86.

Tanaka, T.; Katsuma, S.; Adachi, T.; Koshimizu, T. A.; Hirasawa, A.; Tsujimoto, G.

Free fatty acids induce cholecystokinin secretion through GPR120 Journal Article

In: Naunyn Schmiedebergs Arch. Pharmacol., vol. 377, no. 4-6, pp. 523–527, 2008.

85.

Tanaka, T.; Yano, T.; Adachi, T.; Koshimizu, T. A.; Hirasawa, A.; Tsujimoto, G.

Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells Journal Article

In: Naunyn Schmiedebergs Arch. Pharmacol., vol. 377, no. 4-6, pp. 515–522, 2008.

84.

Oishi, S.; Masuda, R.; Evans, B.; Ueda, S.; Goto, Y.; Ohno, H.; Hirasawa, A.; Tsujimoto, G.; Wang, Z.; Peiper, S. C.; Naito, T.; Kodama, E.; Matsuoka, M.; Fujii, N.

Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4 Journal Article

In: Chembiochem, vol. 9, no. 7, pp. 1154–1158, 2008.

83.

Adachi, T.; Yanaka, H.; Kanai, H.; Nozaki, M.; Takahara, Y.; Tsuda, M.; Jonouchi, T.; Tsuda, K.; Hirasawa, A.; Tsujimoto, G.

Administration of perilla oil coated with Calshell increases glucagon-like peptide secretion Journal Article

In: Biol. Pharm. Bull., vol. 31, no. 5, pp. 1021–1023, 2008.

82.

Ichimura, A.; Kadowaki, T.; Narukawa, K.; Togiya, K.; Hirasawa, A.; Tsujimoto, G.

In silico approach to identify the expression of the undiscovered molecules from microarray public database: identification of odorant receptors expressed in non-olfactory tissues Journal Article

In: Naunyn Schmiedebergs Arch. Pharmacol., vol. 377, no. 2, pp. 159–165, 2008.

81.

Zhang, H.; Ohmi, K.; Hirasawa, A.; Enosawa, S.; Hara, Y.; Tamura, A.; Tsujimoto, G.

Immunological tolerance-related genes in a spontaneous tolerant model of rat liver transplantation explored by suppression subtractive hybridization Journal Article

In: Cell Transplant, vol. 17, no. 1-2, pp. 195–201, 2008.

80.

Hirasawa, A.; Itsubo, C.; Sadakane, K.; Hara, T.; Shinagawa, S.; Koga, H.; Nose, H.; Koshimizu, T. A.; Tsujimoto, G.

Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1) Journal Article

In: Biochem. Biophys. Res. Commun., vol. 365, no. 1, pp. 22–28, 2008.

2007

79.

Gotoh, C.; Hong, Y. H.; Iga, T.; Hishikawa, D.; Suzuki, Y.; Song, S. H.; Choi, K. C.; Adachi, T.; Hirasawa, A.; Tsujimoto, G.; Sasaki, S.; Roh, S. G.

The regulation of adipogenesis through GPR120 Journal Article

In: Biochem. Biophys. Res. Commun., vol. 354, no. 2, pp. 591–597, 2007.

78.

Ruike, Y.; Katsuma, S.; Hirasawa, A.; Tsujimoto, G.

Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A Journal Article

In: J. Hum. Genet., vol. 52, no. 2, pp. 172–178, 2007.

2006

77.

Fukunaga, S.; Setoguchi, S.; Hirasawa, A.; Tsujimoto, G.

Monitoring ligand-mediated internalization of G protein-coupled receptor as a novel pharmacological approach Journal Article

In: Life Sci., vol. 80, no. 1, pp. 17–23, 2006.

76.

Adachi, T.; Tanaka, T.; Takemoto, K.; Koshimizu, T. A.; Hirasawa, A.; Tsujimoto, G.

Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin Journal Article

In: Biochem. Biophys. Res. Commun., vol. 340, no. 1, pp. 332–337, 2006.

75.

Herath, C. B.; Ishiwata, H.; Shiojima, S.; Kadowaki, T.; Katsuma, S.; Ushizawa, K.; Imai, K.; Takahashi, T.; Hirasawa, A.; Takahashi, S.; Izaike, Y.; Tsujimoto, G.; Hashizume, K.

Developmental aberrations of liver gene expression in bovine fetuses derived from somatic cell nuclear transplantation Journal Article

In: Cloning Stem Cells, vol. 8, no. 2, pp. 79–95, 2006.

2005

74.

Katsuma, S.; Hatae, N.; Yano, T.; Ruike, Y.; Kimura, M.; Hirasawa, A.; Tsujimoto, G.

Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1 Journal Article

In: J. Biol. Chem., vol. 280, no. 20, pp. 19507–19515, 2005.

73.

Katsuma, S.; Ruike, Y.; Yano, T.; Kimura, M.; Hirasawa, A.; Tsujimoto, G.

Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells Journal Article

In: FEBS Lett., vol. 579, no. 12, pp. 2576–2582, 2005.

72.

Yamada, M.; Katsuma, S.; Adachi, T.; Hirasawa, A.; Shiojima, S.; Kadowaki, T.; Okuno, Y.; Koshimizu, T. A.; Fujii, S.; Sekiya, Y.; Miyamoto, Y.; Tamura, M.; Yumura, W.; Nihei, H.; Kobayashi, M.; Tsujimoto, G.

Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis Journal Article

In: Proc. Natl. Acad. Sci. U.S.A., vol. 102, no. 21, pp. 7736–7741, 2005.

71.

Katsuma, S.; Hirasawa, A.; Tsujimoto, G.

Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1 Journal Article

In: Biochem. Biophys. Res. Commun., vol. 329, no. 1, pp. 386–390, 2005.

70.

Hirasawa, A.; Tsumaya, K.; Awaji, T.; Katsuma, S.; Adachi, T.; Yamada, M.; Sugimoto, Y.; Miyazaki, S.; Tsujimoto, G.

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 Journal Article

In: Nat. Med., vol. 11, no. 1, pp. 90–94, 2005.

2004

69.

Ushizawa, K.; Herath, C. B.; Kaneyama, K.; Shiojima, S.; Hirasawa, A.; Takahashi, T.; Imai, K.; Ochiai, K.; Tokunaga, T.; Tsunoda, Y.; Tsujimoto, G.; Hashizume, K.

cDNA microarray analysis of bovine embryo gene expression profiles during the pre-implantation period Journal Article

In: Reprod. Biol. Endocrinol., vol. 2, pp. 77, 2004.

68.

Izumi, Y.; Izumiya, Y.; Shiota, M.; Yukimura, T.; Shiojima, S.; Yamada, M.; Kadowaki, T.; Katsuma, S.; Hirasawa, A.; Tsujimoto, G.; Iwao, H.

Gene expression profile in experimental mesangial proliferative glomerulonephritis Journal Article

In: J. Pharmacol. Sci., vol. 96, no. 1, pp. 91–94, 2004.

67.

Koshimizu, T. A.; Tsujimoto, G.; Hirasawa, A.; Kitagawa, Y.; Tanoue, A.

Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha1D- and alpha1B-adrenergic receptors Journal Article

In: Cardiovasc. Res., vol. 63, no. 4, pp. 662–672, 2004.

66.

Herath, C. B.; Shiojima, S.; Ishiwata, H.; Katsuma, S.; Kadowaki, T.; Ushizawa, K.; Imai, K.; Takahashi, T.; Hirasawa, A.; Tsujimoto, G.; Hashizume, K.

Pregnancy-associated changes in genome-wide gene expression profiles in the liver of cow throughout pregnancy Journal Article

In: Biochem. Biophys. Res. Commun., vol. 313, no. 3, pp. 666–680, 2004.

2003

65.

Yamada, M.; Hirasawa, A.; Shiojima, S.; Tsujimoto, G.

Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells Journal Article

In: FASEB J., vol. 17, no. 12, pp. 1712–1714, 2003.

64.

Fukuhara, Y.; Hirasawa, A.; Li, X. K.; Kawasaki, M.; Fujino, M.; Funeshima, N.; Katsuma, S.; Shiojima, S.; Yamada, M.; Okuyama, T.; Suzuki, S.; Tsujimoto, G.

Gene expression profile in the regenerating rat liver after partial hepatectomy Journal Article

In: J. Hepatol., vol. 38, no. 6, pp. 784–792, 2003.

63.

Koshimizu, T. A.; Tanoue, A.; Hirasawa, A.; Yamauchi, J.; Tsujimoto, G.

Recent advances in alpha1-adrenoceptor pharmacology Journal Article

In: Pharmacol. Ther., vol. 98, no. 2, pp. 235–244, 2003.

62.

Ishiwata, H.; Katsuma, S.; Kizaki, K.; Patel, O. V.; Nakano, H.; Takahashi, T.; Imai, K.; Hirasawa, A.; Shiojima, S.; Ikawa, H.; Suzuki, Y.; Tsujimoto, G.; Izaike, Y.; Todoroki, J.; Hashizume, K.

Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray Journal Article

In: Mol. Reprod. Dev., vol. 65, no. 1, pp. 9–18, 2003.

61.

Richardson, J.; Chatwin, H.; Hirasawa, A.; Tsujimoto, G.; Evans, P. D.

Agonist-specific coupling of a cloned human alpha1A-adrenoceptor to different second messenger pathways Journal Article

In: Naunyn Schmiedebergs Arch. Pharmacol., vol. 367, no. 4, pp. 333–341, 2003.

60.

Nakamura, T.; Shiojima, S.; Hirai, Y.; Iwama, T.; Tsuruzoe, N.; Hirasawa, A.; Katsuma, S.; Tsujimoto, G.

Temporal gene expression changes during adipogenesis in human mesenchymal stem cells Journal Article

In: Biochem. Biophys. Res. Commun., vol. 303, no. 1, pp. 306–312, 2003.

59.

Katsuma, S.; Hada, Y.; Shiojima, S.; Hirasawa, A.; Tanoue, A.; Takagaki, K.; Ohgi, T.; Yano, J.; Tsujimoto, G.

Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation Journal Article

In: Biochem. Biophys. Res. Commun., vol. 300, no. 2, pp. 577–584, 2003.

58.

Shibata, K.; Katsuma, S.; Koshimizu, T.; Shinoura, H.; Hirasawa, A.; Tanoue, A.; Tsujimoto, G.

alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1 Journal Article

In: J. Biol. Chem., vol. 278, no. 1, pp. 672–678, 2003.

2002

57.

Katsuma, S.; Hada, Y.; Ueda, T.; Shiojima, S.; Hirasawa, A.; Tanoue, A.; Takagaki, K.; Ohgi, T.; Yano, J.; Tsujimoto, G.

Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation Journal Article

In: Genes Cells, vol. 7, no. 12, pp. 1217–1230, 2002.

56.

Shinoura, H.; Shibata, K.; Hirasawa, A.; Tanoue, A.; Hashimoto, K.; Tsujimoto, G.

Key amino acids for differential coupling of alpha1-adrenergic receptor subtypes to Gs Journal Article

In: Biochem. Biophys. Res. Commun., vol. 299, no. 1, pp. 142–147, 2002.

55.

Yamauchi, J.; Miyamoto, Y.; Kokubu, H.; Nishii, H.; Okamoto, M.; Sugawara, Y.; Hirasawa, A.; Tsujimoto, G.; Itoh, H.

Endothelin suppresses cell migration via the JNK signaling pathway in a manner dependent upon Src kinase, Rac1, and Cdc42 Journal Article

In: FEBS Lett., vol. 527, no. 1-3, pp. 284–288, 2002.

54.

Katsuma, S.; Shiojima, S.; Hirasawa, A.; Takagaki, K.; Kaminishi, Y.; Koba, M.; Hagidai, Y.; Murai, M.; Ohgi, T.; Yano, J.; Tsujimoto, G.

Global analysis of differentially expressed genes during progression of calcium oxalate nephrolithiasis Journal Article

In: Biochem. Biophys. Res. Commun., vol. 296, no. 3, pp. 544–552, 2002.

53.

Yamauchi, J.; Hirasawa, A.; Miyamoto, Y.; Kokubu, H.; Nishii, H.; Okamoto, M.; Sugawara, Y.; Tsujimoto, G.; Itoh, H.

Role of Dbl's big sister in the anti-mitogenic pathway from alpha1B-adrenergic receptor to c-Jun N-terminal kinase Journal Article

In: Biochem. Biophys. Res. Commun., vol. 296, no. 1, pp. 85–92, 2002.

152 entries « ‹ 2 of 4 › »