@article{GOTO2024294,

title = {Analyses of the onset mechanisms of cardio-stimulatory action by aciclovir},

author = {Ai Goto and Ryuichi Kambayashi and Koki Chiba and Makoto Shinozaki and Kiryu Moritani and Hiroko Izumi-Nakaseko and Yoshinori Takei and Akira Hirasawa and Atsushi Sugiyama},

url = {https://www.sciencedirect.com/science/article/pii/S1347861324000148},

doi = {https://doi.org/10.1016/j.jphs.2024.02.005},

issn = {1347-8613},

year  = {2024},

date = {2024-01-01},

journal = {Journal of Pharmacological Sciences},

volume = {154},

number = {4},

pages = {294-300},

abstract = {Cardio-stimulatory actions of aciclovir have been considered to primarily depend on the sympathetically-mediated reflex resulting from its hypotensive effect. To further clarify onset mechanisms of the cardio-stimulatory actions, we initially studied them using isoflurane-anesthetized dogs under thorough β1-adrenoceptor blockade with atenolol (1 mg/kg, i.v.) (n = 4). Aciclovir (20 mg/kg/10 min, i.v.) decreased mean arterial blood pressure by 10 mmHg, whereas it increased heart rate by 10 bpm and maximum upstroke velocity of ventricular pressure by 928 mmHg/s, and shortened AH interval by 2 ms, indicating that cardio-stimulatory actions were not totally abolished by β1-adrenoceptor blockade. Then, unknown mechanisms of cardio-stimulatory action were explored. Since aciclovir has a similar chemical structure to theophylline, in silico molecular docking simulation was performed, indicating aciclovir as well as theophylline possesses strong likelihood of interactions with phosphodiesterase 1A, 1C and 3A. Indeed, aciclovir inhibited phosphodiesterase 1A derived from the bovine heart (n = 4), moreover it exerted positive chronotropic action on the atrial tissue preparation of rats along with an increase of tissue cyclic AMP concentration (n = 4). These results indicate that cardio-stimulatory actions of aciclovir could result from not only hypotension-induced, reflex-mediated increase of sympathetic tone but also its inhibitory effects on phosphodiesterase in the heart.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37648998,

title = {BCL7B, a SWI/SNF complex subunit, orchestrates cancer immunity and stemness},

author = {Sayaka Higuchi and Yuji Suehiro and Luna Izuhara and Sawako Yoshina and Akira Hirasawa and Shohei Mitani},

doi = {10.1186/s12885-023-11321-3},

issn = {1471-2407},

year  = {2023},

date = {2023-08-01},

journal = {BMC Cancer},

volume = {23},

number = {1},

pages = {811},

abstract = {Cancer is one of the main causes of human death. Here, we focus on the B-cell lymphoma 7 protein family member B (BCL7B) gene, an accessory subunit of the SWI/SNF chromatin-remodelling complex. To characterize the function of BCL7B, heterozygous BCL7B-deficient stomach cancer cell lines were generated with the CRISPR/Cas9 genome editing system. The comprehensive gene expression patterns were compared between parental cells and each ΔBCL7B cell line by RNA-seq. The results showed marked downregulation of immune-related genes and upregulation of stemness-related genes in the ΔBCL7B cell lines. Moreover, by ChIP-seq analysis with H3K27me3 antibody, the changes of epigenetic modification sequences were compared between parental cells and each ΔBCL7B cell line. After machine learning, we detected the centroid sequence changes, which exerted an impact on antigen presentation. The regulation of BCL7B expression in cancer cells gives rise to cancer stem cell-like characteristics and the acquisition of an immune evasion phenotype.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid37074989b,

title = {Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding},

author = {Takuma Yasuda and Norio Harada and Tomonobu Hatoko and Atsuhiko Ichimura and Eri Ikeguchi-Ogura and Yuki Murata and Naoki Wada and Sakura Kiyobayashi and Shunsuke Yamane and Akira Hirasawa and Nobuya Inagaki},

doi = {10.1152/ajpendo.00329.2022},

issn = {1522-1555},

year  = {2023},

date = {2023-05-01},

journal = {Am J Physiol Endocrinol Metab},

volume = {324},

number = {5},

pages = {E449--E460},

abstract = {G protein-coupled receptor (GPR) 120 is expressed in enteroendocrine cells secreting glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP), and cholecystokinin (CCK). Although GPR120 signaling in adipose tissue and macrophages has been reported to ameliorate obesity and insulin resistance in a high long-chain triglyceride (LCT) diet, intestine-specific roles of GPR120 are unclear. To clarify the metabolic effect of GPR120 in the intestine, we generated intestine-specific GPR120-knockout () mice. In comparison with floxed GPR120 (WT) mice,  mice exhibited reduced GIP secretion and CCK action without change of insulin, GLP-1, or peptide YY (PYY) secretion after a single administration of LCT. Under a high-LCT diet,  mice showed a mild reduction of body weight and substantial amelioration of insulin resistance and fatty liver. Moreover, liver and white adipose tissue (WAT) of mice exhibited increased Akt phosphorylation and reduced gene expression of suppressor of cytokine signaling (SOCS) 3, which inhibits insulin signaling. In addition, gene expression of inflammatory cytokines in WAT and lipogenic molecules in liver were reduced in  mice. These findings suggest that inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-LCT diet feeding. We generated novel intestine-specific GPR120-knockout () mice and investigated the metabolic effect of GPR120 in the intestine.  mice exhibited a reduction of GIP secretion and CCK action after a single administration of LCT. Under a high-LCT diet,  mice showed mild improvement in obesity and marked amelioration of insulin resistance and hepatic steatosis. Our results indicate an important role of intestinal GPR120 on insulin resistance and hepatic steatosis.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/37046360,

title = {Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory.},

author = {Yoshinori Takei and Yoko Amagase and Keiko Iida and Tomohiro Sagawa and Ai Goto and Ryuichi Kambayashi and Hiroko Izumi-Nakaseko and Akio Matsumoto and Shinichi Kawai and Atsushi Sugiyama and Tatsuyuki Takada and Akira Hirasawa},

doi = {10.1007/s11357-022-00579-3},

year  = {2022},

date = {2022-01-01},

journal = {GeroScience},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/37046033,

title = {A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus.},

author = {Kensuke Iwasa and Shinji Yamamoto and Kota Yamashina and Nan Yagishita-Kyo and Kei Maruyama and Takeo Awaji and Yoshinori Takei and Akira Hirasawa and Keisuke Yoshikawa},

doi = {10.1186/s12974-021-02361-2},

year  = {2021},

date = {2021-01-01},

journal = {Journal of neuroinflammation},

volume = {18},

number = {1},

pages = {304--304},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/35009867,

title = {Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK},

author = {Yuki Murata and Norio Harada and Shigenobu Kishino and Kanako Iwasaki and Eri Ikeguchi-Ogura and Shunsuke Yamane and Tomoko Kato and Yoshinori Kanemaru and Akiko Sankoda and Tomonobu Hatoko and Sakura Kiyobayashi and Jun Ogawa and Akira Hirasawa and Nobuya Inagaki},

doi = {10.1016/j.isci.2021.102963},

year  = {2021},

date = {2021-01-01},

journal = {iScience},

volume = {24},

number = {9},

pages = {102963--102963},

publisher = {Elsevier BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/32825132,

title = {In vivo emergence of beige-like fat in chickens as physiological adaptation to cold environments},

author = {Rina Sotome and Akira Hirasawa and Motoi Kikusato and Taku Amo and Kyohei Furukawa and Anna Kuriyagawa and Kouichi Watanabe and Anne Collin and Hitoshi Shirakawa and Ryota Hirakawa and Yuta Tanitaka and Hideki Takahashi and Guoyao Wu and Tomonori Nochi and Tsuyoshi Shimmura and Craig H. Warden and Masaaki Toyomizu},

doi = {10.1007/s00726-021-02953-5},

year  = {2021},

date = {2021-01-01},

journal = {Amino Acids},

volume = {53},

number = {3},

pages = {381--393},

publisher = {Springer Science and Business Media LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/35196574,

title = {FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice.},

author = {Yuko Sadamura and Shanta Thapa and Ryota Mizunuma and Yuki Kambe and Akira Hirasawa and Kazuo Nakamoto and Shogo Tokuyama and Koji Yoshimoto and Kazunori Arita and Atsuro Miyata and Tatsuki Oyoshi and Takashi Kurihara},

doi = {10.3389/fphar.2021.699026},

year  = {2021},

date = {2021-01-01},

journal = {Frontiers in pharmacology},

volume = {12},

pages = {699026--699026},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/28433481,

title = {Molecular Mechanism of Apoptosis by Amyloid β-Protein Fibrils Formed on Neuronal Cells},

author = {Eri Takada and Kaori Okubo and Yoshiaki Yano and Keiko Iida and Masataka Someda and Akira Hirasawa and Shin Yonehara and Katsumi Matsuzaki},

doi = {10.1021/acschemneuro.0c00011},

year  = {2020},

date = {2020-01-01},

journal = {ACS Chemical Neuroscience},

volume = {11},

number = {5},

pages = {796--805},

publisher = {American Chemical Society (ACS)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/27419421,

title = {Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176},

author = {Tianyu Wang and Shumpei Nakagawa and Takahito Miyake and Genzui Setsu and Sumihiro Kunisue and Kaoru Goto and Akira Hirasawa and Hitoshi Okamura and Yoshiaki Yamaguchi and Masao Doi},

year  = {2020},

date = {2020-01-01},

journal = {Scientific Reports},

volume = {10},

pages = {4429--},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/34108970,

title = {Structural insights for producing CK2α1-specific inhibitors.},

author = {Masato Tsuyuguchi and Tetsuko Nakaniwa and Akira Hirasawa and Isao Nakanishi and Takayoshi Kinoshita},

doi = {10.1016/j.bmcl.2019.126837},

year  = {2020},

date = {2020-01-01},

journal = {Bioorganic & medicinal chemistry letters},

volume = {30},

number = {2},

pages = {126837--126837},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/26924607,

title = {Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1},

author = {Katsutoshi Nishino and Haruka Uesugi and Akira Hirasawa and Anna Ohtera and Yusaku Miyamae and Mohamed Neffati and Hiroko Isoda and Taiho Kambe and Seiji Masuda and Kazuhiro Irie and Masaya Nagao},

doi = {10.1016/j.bbrc.2019.11.037},

year  = {2019},

date = {2019-01-01},

journal = {Biochemical and biophysical research communications},

volume = {522},

number = {1},

pages = {68--73},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/34818421,

title = {Free fatty acid receptors, G protein-coupled receptor 120 and G protein-coupled receptor 40, are essential for oil-induced gastric inhibitory polypeptide secretion.},

author = {Akiko Sankoda and Norio Harada and Tomoko Kato and Eri Ikeguchi and Kanako Iwasaki and Shunsuke Yamane and Yuki Murata and Akira Hirasawa and Nobuya Inagaki},

doi = {10.1111/jdi.13059},

year  = {2019},

date = {2019-01-01},

journal = {Journal of diabetes investigation},

volume = {10},

number = {6},

pages = {1430--1437},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/37060252,

title = {Transcriptome analysis revealed bisphenol A and nonylphenol affect reproduction.},

author = {Tomoaki Tanaka and Yuriko Ono and Naoki Hikihara and Ayana Yoshida and Hasumi Yamada and Shogo Higaki and Tomomi Nishie and Ikuo Tooyama and Keiko Iida and Akira Hirasawa and Tatsuyuki Takada},

doi = {10.1016/j.reprotox.2019.06.006},

year  = {2019},

date = {2019-01-01},

journal = {Reproductive toxicology (Elmsford, N.Y.)},

volume = {88},

pages = {39--47},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/27104858,

title = {Free fatty acid receptor GPR120 and GPR40 are essential for oil-induced GIP secretion.},

year  = {2019},

date = {2019-01-01},

journal = {J Diabetes Investig.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/22752873,

title = {Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance.},

author = {Koshimizu TA and Honda K and Nagaoka-Uozumi S and Ichimura A and Kimura I and Nakaya M and Sakai N and Shibata K and Ushijima K and Fujimura A and Hirasawa A and Kurose H and Tsujimoto G and Tanoue A and Takano Y},

doi = {10.1038/s41593-018-0144-y},

year  = {2018},

date = {2018-01-01},

journal = {Nature neuroscience},

volume = {21},

number = {6},

pages = {820--833},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/22752874,

title = {DHA supplementation prevent the progression of NASH via GPR120 signaling},

author = {Kazuo Nakamoto and Koki Shimada and Shinichi Harada and Yasuko Morimoto and Akira Hirasawa and Shogo Tokuyama},

doi = {10.1016/j.ejphar.2017.11.046},

year  = {2018},

date = {2018-01-01},

journal = {European Journal of Pharmacology},

volume = {820},

pages = {31--38},

publisher = {Elsevier B.V.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/22752875,

title = {The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice},

author = {Fuka Aizawa and Yoshihiro Ogaki and Natsuki Kyoya and Takashi Nishinaka and Kazuo Nakamoto and Takashi Kurihara and Akira Hirasawa and Atsuro Miyata and Shogo Tokuyama},

doi = {10.1248/bpb.b17-00082},

year  = {2017},

date = {2017-01-01},

journal = {BIOLOGICAL & PHARMACEUTICAL BULLETIN},

volume = {40},

number = {8},

pages = {1255--1259},

publisher = {PHARMACEUTICAL SOC JAPAN},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/22752876,

title = {Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice},

author = {Kazuo Nakamoto and Fuka Aizawa and Kei Miyagi and Takuya Yamashita and Mitsumasa Mankura and Yutaka Koyama and Fumiyo Kasuya and Akira Hirasawa and Takashi Kurihara and Atsuro Miyata and Shogo Tokuyama},

doi = {10.1371/journal.pone.0180610},

year  = {2017},

date = {2017-01-01},

journal = {PLOS ONE},

volume = {12},

number = {7},

pages = {e0180610--},

publisher = {PUBLIC LIBRARY SCIENCE},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/22752877,

title = {Intermittent hypoxia produces Alzheimer disease?},

author = {Sosuke Yagishita and Akira Hirasawa},

doi = {10.18632/oncotarget.18214},

year  = {2017},

date = {2017-01-01},

journal = {ONCOTARGET},

volume = {8},

number = {26},

pages = {41786--41787},

publisher = {IMPACT JOURNALS LLC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/17508117,

title = {Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance},

author = {Julia M. Houthuijzen and Ilse Oosterom and Brian D. Hudson and Akira Hirasawa and Laura G. M. Daenen and Chelsea M. McLean and Steffen V. F. Hansen and Marijn T. M. Jaarsveld and Daniel S. Peeper and Sahar Jafari Sadatmand and Jeanine M. L. Roodhart and Chris H. A. Lest and Trond Ulven and Kenji Ishihara and Graeme Milligan and Emile E. Voest},

doi = {10.1096/fj.201601248R},

year  = {2017},

date = {2017-01-01},

journal = {FASEB JOURNAL},

volume = {31},

number = {5},

pages = {2195--2209},

publisher = {FEDERATION AMER SOC EXP BIOL},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/17508013,

title = {Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice},

author = {Akiko Sankoda and Norio Harada and Kanako Iwasaki and Shunsuke Yamane and Yuki Murata and Kimitaka Shibue and Yotsapon Thewjitcharoen and Kazuyo Suzuki and Takanari Harada and Yoshinori Kanemaru and Satoko Shimazu-Kuwahara and Akira Hirasawa and Nobuya Inagaki},

doi = {10.1210/en.2017-00090},

year  = {2017},

date = {2017-01-01},

journal = {ENDOCRINOLOGY},

volume = {158},

number = {5},

pages = {1172--1180},

publisher = {ENDOCRINE SOC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/27100107,

title = {Effects of arachidonic acid on FFA4 receptor: Signaling, phosphorylation and internalization},

author = {S. Villegas-Comonfort and Y. Takei and G. Tsujimoto and A. Hirasawa and J. A. Garcia-Sainz},

doi = {10.1016/j.plefa.2017.01.013},

year  = {2017},

date = {2017-01-01},

journal = {PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS},

volume = {117},

pages = {1--10},

publisher = {ELSEVIER SCI LTD},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/16398355,

title = {Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging},

author = {Sosuke Yagishita and Seiya Suzuki and Keisuke Yoshikawa and Keiko Iida and Ayako Hirata and Masahiko Suzuki and Akihiko Takashima and Kei Maruyama and Akira Hirasawa and Takeo Awaji},

doi = {10.1186/s13041-016-0282-7},

year  = {2017},

date = {2017-01-01},

journal = {MOLECULAR BRAIN},

volume = {10},

number = {1},

pages = {2--},

publisher = {BIOMED CENTRAL LTD},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/26704706,

title = {GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior},

author = {Fuka Aizawa and Takashi Nishinaka and Takuya Yamashita and Kazuo Nakamoto and Takashi Kurihara and Akira Hirasawa and Fumiyo Kasuya and Atsuro Miyata and Shogo Tokuyama},

doi = {10.1016/j.jphs.2016.09.007},

year  = {2016},

date = {2016-01-01},

journal = {JOURNAL OF PHARMACOLOGICAL SCIENCES},

volume = {132},

number = {4},

pages = {249--254},

publisher = {JAPANESE PHARMACOLOGICAL SOC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid25489006,

title = {The oral lipid sensor GPR120 is not indispensable for the orosensory detection of dietary lipids in mice},

author = {D. Ancel and A. Bernard and S. Subramaniam and A. Hirasawa and G. Tsujimoto and T. Hashimoto and P. Passilly-Degrace and N. A. Khan and P. Besnard},

doi = {10.1194/jlr.M055202},

year  = {2015},

date = {2015-02-01},

urldate = {2015-02-01},

journal = {J. Lipid Res.},

volume = {56},

number = {2},

pages = {369--378},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/14179683,

title = {Agonists and protein kinase C-activation induce phosphorylation and internalization of FFA1 receptors},

author = {Carla Sosa-Alvarado and Aurelio Hernandez-Mendez and M. Teresa Romero-Avila and Omar B. Sanchez-Reyes and Yoshinori Takei and Gozoh Tsujimoto and Akira Hirasawa and J. Adolfo Garcia-Sainz},

doi = {10.1016/j.ejphar.2015.10.038},

year  = {2015},

date = {2015-01-01},

journal = {EUROPEAN JOURNAL OF PHARMACOLOGY},

volume = {768},

pages = {108--115},

publisher = {ELSEVIER SCIENCE BV},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/14179685,

title = {The Effects of a Selective CK2 Inhibitor on Anti-glomerular Basement Membrane Glomerulonephritis in Rats},

author = {Junfeng Shi and Ning Liu and Ying Xiao and Yoshinori Takei and Misato Yasue and Yamato Suzuki and Zengye Hou and Hiroaki Ohno and Masateru Yamada and Nobuhiro Fuchi and Keiyu Oshida and Yohei Miyamoto and Gozoh Tsujimoto and Akira Hirasawa},

doi = {10.1248/bpb.b15-00195},

year  = {2015},

date = {2015-01-01},

journal = {BIOLOGICAL & PHARMACEUTICAL BULLETIN},

volume = {38},

number = {9},

pages = {1345--1351},

publisher = {PHARMACEUTICAL SOC JAPAN},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/14179686,

title = {Effects of a Tricaprylin Emulsion on Anti-glomerular Basement Membrane Glomerulonephritis in Rats: In Vivo and in Silico Studies},

author = {Ning Liu and Junfeng Shi and Ying Xiao and Misato Yasue and Yoshinori Takei and Hayato Sanefuji and Gozoh Tsujimoto and Akira Hirasawa},

doi = {10.1248/bpb.b15-00124},

year  = {2015},

date = {2015-01-01},

journal = {BIOLOGICAL & PHARMACEUTICAL BULLETIN},

volume = {38},

number = {8},

pages = {1175--1184},

publisher = {PHARMACEUTICAL SOC JAPAN},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/13173557,

title = {Identification of protein kinase CK2 inhibitors using solvent dipole ordering virtual screening},

author = {Isao Nakanishi and Katsumi Murata and Naoya Nagata and Masakuni Kurono and Takayoshi Kinoshita and Misato Yasue and Takako Miyazaki and Yoshinori Takei and Shinya Nakamura and Atsushi Sakurai and Nobuko Iwamoto and Keiji Nishiwaki and Tetsuko Nakaniwa and Yusuke Sekiguchi and Akira Hirasawa and Gozoh Tsujimoto and Kazuo Kitaura},

doi = {10.1016/j.ejmech.2015.04.032},

year  = {2015},

date = {2015-01-01},

journal = {EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY},

volume = {96},

pages = {396--404},

publisher = {ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/13173556,

title = {The oral lipid sensor GPR120 is not indispensable for the orosensory detection of dietary lipids in mice},

author = {Deborah Ancel and Arnaud Bernard and Selvakumar Subramaniam and Akira Hirasawa and Gozoh Tsujimoto and Toshihiro Hashimoto and Patricia Passilly-Degrace and Naim-Akhtar Khan and Philippe Besnard},

doi = {10.1194/jlr.M055202},

year  = {2015},

date = {2015-01-01},

journal = {JOURNAL OF LIPID RESEARCH},

volume = {56},

number = {2},

pages = {369--378},

publisher = {AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/29651028,

title = {Fatty acids receptors},

author = {Akira Hirasawa and Masato Takeuchi and Takafumi Hara and Ayako Hirata and Soshi Tanabe and Naoya Umeda},

doi = {10.1007/978-4-431-55669-5_10},

year  = {2015},

date = {2015-01-01},

journal = {Bioactive Lipid Mediators: Current Reviews and Protocols},

pages = {139--154},

publisher = {Springer Japan},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/25810026,

title = {Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.},

author = {Iwasaki K and Harada N and Sasaki K and Yamane S and Iida K and Suzuki K and Hamasaki A and Nasteska D and Shibue K and Joo E and Harada T and Hashimoto T and Asakawa Y and Hirasawa A and Inagaki N},

doi = {10.1210/en.2014-1653},

year  = {2015},

date = {2015-01-01},

journal = {Endocrinology.},

volume = {156},

number = {3},

pages = {837--846},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{published_papers/13803166,

title = {Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120.},

author = {Akiko Furutani and Yuko Ikeda and Misa Itokawa and Hiroki Nagahama and Teiji Ohtsu and Naoki Furutani and Mayo Kamagata and Zhi-Hong Yang and Akira Hirasawa and Yu Tahara and Shigenobu Shibata},

doi = {10.1371/journal.pone.0132472},

year  = {2015},

date = {2015-01-01},

journal = {PloS one},

volume = {10},

number = {7},

pages = {e0132472--},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid25535828,

title = {Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K-cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion},

author = {K. Iwasaki and N. Harada and K. Sasaki and S. Yamane and K. Iida and K. Suzuki and A. Hamasaki and D. Nasteska and K. Shibue and E. Joo and T. Harada and T. Hashimoto and Y. Asakawa and A. Hirasawa and N. Inagaki},

doi = {10.1210/en.2014-1653},

year  = {2014},

date = {2014-12-01},

urldate = {2014-12-01},

journal = {Endocrinology},

pages = {en20141653},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid24923869,

title = {Role of free fatty acid receptors in the regulation of energy metabolism},

author = {T. Hara and D. Kashihara and A. Ichimura and I. Kimura and G. Tsujimoto and A. Hirasawa},

doi = {10.1016/j.bbalip.2014.06.002},

year  = {2014},

date = {2014-09-01},

urldate = {2014-09-01},

journal = {Biochim. Biophys. Acta},

volume = {1841},

number = {9},

pages = {1292--1300},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid24857775,

title = {Design and synthesis of fluorescent probes for GPR54},

author = {M. Kaneda and R. Misu and H. Ohno and A. Hirasawa and N. Ieda and Y. Uenoyama and H. Tsukamura and K. Maeda and S. Oishi and N. Fujii},

doi = {10.1016/j.bmc.2014.04.052},

year  = {2014},

date = {2014-07-01},

urldate = {2014-07-01},

journal = {Bioorg. Med. Chem.},

volume = {22},

number = {13},

pages = {3325--3330},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid25071726,

title = {Regulation of Energy Homeostasis via GPR120},

author = {A. Ichimura and T. Hara and A. Hirasawa},

doi = {10.3389/fendo.2014.00111},

year  = {2014},

date = {2014-01-01},

urldate = {2014-01-01},

journal = {Front Endocrinol (Lausanne)},

volume = {5},

pages = {111},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid24917851,

title = {Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors},

author = {T. Hara and A. Ichimura and A. Hirasawa},

doi = {10.3389/fendo.2014.00083},

year  = {2014},

date = {2014-01-01},

urldate = {2014-01-01},

journal = {Front Endocrinol (Lausanne)},

volume = {5},

pages = {83},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid24239485,

title = {Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation},

author = {O. B. Sanchez-Reyes and M. T. Romero-Avila and J. A. Castillo-Badillo and Y. Takei and A. Hirasawa and G. Tsujimoto and R. Villalobos-Molina and J. A. Garcia-Sainz},

doi = {10.1016/j.ejphar.2013.11.003},

year  = {2014},

date = {2014-01-01},

urldate = {2014-01-01},

journal = {Eur. J. Pharmacol.},

volume = {723},

pages = {368--374},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid23535832,

title = {Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors},

author = {Z. Hou and S. Oishi and Y. Suzuki and T. Kure and I. Nakanishi and A. Hirasawa and G. Tsujimoto and H. Ohno and N. Fujii},

doi = {10.1039/c3ob40223a},

year  = {2013},

date = {2013-05-01},

urldate = {2013-05-01},

journal = {Org. Biomol. Chem.},

volume = {11},

number = {20},

pages = {3288--3296},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid22639973,

title = {FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models},

author = {M. Takeuchi and A. Hirasawa and T. Hara and I. Kimura and T. Hirano and T. Suzuki and N. Miyata and T. Awaji and M. Ishiguro and G. Tsujimoto},

doi = {10.1111/j.1476-5381.2012.02052.x},

year  = {2013},

date = {2013-04-01},

urldate = {2013-04-01},

journal = {Br. J. Pharmacol.},

volume = {168},

number = {7},

pages = {1570--1583},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid23229634,

title = {Physiological functions of fatty acid receptors and their therapeutic potential},

author = {T. Hara and A. Hirasawa and A. Ichimura and I. Kimura and G. Tsujimoto},

doi = {10.1254/fpj.140.275},

year  = {2012},

date = {2012-12-01},

urldate = {2012-12-01},

journal = {Nippon Yakurigaku Zasshi},

volume = {140},

number = {6},

pages = {275--279},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid22610034,

title = {Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles},

author = {Y. Suzuki and S. Oishi and Y. Takei and M. Yasue and R. Misu and S. Naoe and Z. Hou and T. Kure and I. Nakanishi and H. Ohno and A. Hirasawa and G. Tsujimoto and N. Fujii},

doi = {10.1039/c2ob25298h},

year  = {2012},

date = {2012-07-01},

urldate = {2012-07-01},

journal = {Org. Biomol. Chem.},

volume = {10},

number = {25},

pages = {4907--4915},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid22486464,

title = {Paradoxical Downregulation of CXC Chemokine Receptor 4 Induced by Polyphemusin II-Derived Antagonists},

author = {R. Masuda and S. Oishi and N. Tanahara and H. Ohno and A. Hirasawa and G. Tsujimoto and Y. Yano and K. Matsuzaki and J. M. Navenot and S. C. Peiper and N. Fujii},

doi = {10.1021/bc300084h},

year  = {2012},

date = {2012-06-01},

urldate = {2012-06-01},

journal = {Bioconjug. Chem.},

volume = {23},

number = {6},

pages = {1259--1265},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid22571609,

title = {Development and application of fluorescent SDF-1 derivatives},

author = {R. Masuda and S. Oishi and N. Tanahara and H. Ohno and A. Hirasawa and G. Tsujimoto and E. Kodama and M. Matsuoka and N. Fujii},

doi = {10.4155/fmc.12.31},

year  = {2012},

date = {2012-05-01},

urldate = {2012-05-01},

journal = {Future Med Chem},

volume = {4},

number = {7},

pages = {837--844},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid22673524,

title = {Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation},

author = {D. Inoue and I. Kimura and M. Wakabayashi and H. Tsumoto and K. Ozawa and T. Hara and Y. Takei and A. Hirasawa and Y. Ishihama and G. Tsujimoto},

doi = {10.1016/j.febslet.2012.04.021},

year  = {2012},

date = {2012-05-01},

urldate = {2012-05-01},

journal = {FEBS Lett.},

volume = {586},

number = {10},

pages = {1547--1554},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid22339433,

title = {Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds},

author = {Z. Hou and I. Nakanishi and T. Kinoshita and Y. Takei and M. Yasue and R. Misu and Y. Suzuki and S. Nakamura and T. Kure and H. Ohno and K. Murata and K. Kitaura and A. Hirasawa and G. Tsujimoto and S. Oishi and N. Fujii},

doi = {10.1021/jm2015167},

year  = {2012},

date = {2012-03-01},

urldate = {2012-03-01},

journal = {J. Med. Chem.},

volume = {55},

number = {6},

pages = {2899--2903},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid22343897,

title = {Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human},

author = {A. Ichimura and A. Hirasawa and O. Poulain-Godefroy and A. Bonnefond and T. Hara and L. Yengo and I. Kimura and A. Leloire and N. Liu and K. Iida and H. Choquet and P. Besnard and C. Lecoeur and S. Vivequin and K. Ayukawa and M. Takeuchi and K. Ozawa and M. Tauber and C. Maffeis and A. Morandi and R. Buzzetti and P. Elliott and A. Pouta and M. R. Jarvelin and A. Korner and W. Kiess and M. Pigeyre and R. Caiazzo and W. Van Hul and L. Van Gaal and F. Horber and B. Balkau and C. Levy-Marchal and K. Rouskas and A. Kouvatsi and J. Hebebrand and A. Hinney and A. Scherag and F. Pattou and D. Meyre and T. A. Koshimizu and I. Wolowczuk and G. Tsujimoto and P. Froguel},

doi = {10.1038/nature10798},

year  = {2012},

date = {2012-03-01},

urldate = {2012-03-01},

journal = {Nature},

volume = {483},

number = {7389},

pages = {350--354},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid21735094,

title = {A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase},

author = {T. Kinoshita and Y. Sekiguchi and H. Fukada and T. Nakaniwa and T. Tada and S. Nakamura and K. Kitaura and H. Ohno and Y. Suzuki and A. Hirasawa and I. Nakanishi and G. Tsujimoto},

doi = {10.1007/s11010-011-0960-9},

year  = {2011},

date = {2011-10-01},

urldate = {2011-10-01},

journal = {Mol. Cell. Biochem.},

volume = {356},

number = {1-2},

pages = {97--105},

keywords = {},

pubstate = {published},

tppubtype = {article}

}